Therapeutic intervention based on protein prenylation and associated modifications
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چکیده
منابع مشابه
Therapeutic intervention based on protein prenylation and associated modifications.
In eukaryotic cells, a specific set of proteins are modified by C-terminal attachment of 15-carbon farnesyl groups or 20-carbon geranylgeranyl groups that function both as anchors for fixing proteins to membranes and as molecular handles for facilitating binding of these lipidated proteins to other proteins. Additional modification of these prenylated proteins includes C-terminal proteolysis an...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2006
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio818